Synthesis and pharmacology of 1-methoxy analogs of CP-47,497.
نویسندگان
چکیده
Three 1-methoxy analogs of CP-47,497 (7, 8, and 19) have been synthesized and their affinities for the cannabinoid CB(1) and CB(2) receptors have been determined. Although these compounds exhibit selectivity for the CB(2) receptor none have significant affinity for either receptor. Modeling and receptor docking studies were carried out, which provide a rationalization for the weak affinities of these compounds for either receptor.
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ورودعنوان ژورنال:
- Bioorganic & medicinal chemistry
دوره 18 15 شماره
صفحات -
تاریخ انتشار 2010